Science & technology

Research policy, public funding decisions and the preprints that arrive before peer review.

Updated · 2026-09-20 22:10 UTC38

Today’s lead story

Hepatic Xanthine Oxidoreductase Sustains Antithrombotic Nitric Oxide Signalling Through the Nitrate-Nitrite-Nitric Oxide Pathway

Background: Tonic endothelium-derived nitric oxide (NO) suppresses platelet activation physiologically, and its loss underlies the thrombotic risk of endothelial dysfunction. Inorganic nitrate and nitrite provide an alternative NO source, and xanthine oxidoreductase (XOR) is a candidate nitrite reductase, but whether endogenous XOR sustains platelet NO signalling in vivo, and its source is unknown

Science & technologyPipeline & developmentbioRxiv (Pharmacology)2026-09-19

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Science & technologyOfficial intelligenceNASAUS2026-09-18

Albania to sign NASA's Artemis Accords, expanding international space cooperation

Albania will sign the Artemis Accords, joining nations committed to responsible space exploration. This expands the international framework for lunar and deep space missions, fostering global collaboration.

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Science & technologyOfficial intelligenceNASAUS2026-09-18

NASA-JAXA XRISM Mission Observes Pulsar Interacting with Companion’s ‘Wind’

The NASA-JAXA XRISM mission has provided new insights into a pulsar's interaction with its companion star's stellar wind. This breakthrough advances our understanding of high-energy astrophysical phenomena.

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Official intelligence

Confirmed rules and announcements from government bodies, regulators and official journals.

Science & technologyNASAUS2026-09-18

NASA Awards SpaceX Three Crew Flights to Space Station

NASA has contracted SpaceX for three additional crewed missions to the International Space Station. This secures continued US access to the ISS and supports ongoing space research and operations.

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Pipeline & development

Work in progress: clinical trials, company disclosures, preprints and safety notices.

Science & technologybioRxiv (Pharmacology)2026-09-18

Multispecies translational evaluation of an NMDA receptor modulator reveals analgesic, autonomic-stabilizing, and stress mitigating effects without evidence of abuse liability

CNS4 is an agonist concentration-biased NMDAR modulator exhibiting GluN2 subtype-dependent activity. Here we evaluated the translational pharmacology of CNS4 across mice, rats, and client-owned surgical oncology dogs. In mice, CNS4 did not produce conditioned place preference, indicating lack of reward liability. CNS4 produced dose-dependent reductions in locomotor activity without motor impairmen

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Science & technologybioRxiv (Pharmacology)2026-09-18

Cinnamaldehyde interacts with the local anesthetic pocket of the NaV 1.5 channel

Cinnamaldehyde (CA) is extensively used as flavorant and in traditional medicine. CA is com-monly used in pain research as specific agonist of TRPA1, a polymodal cation channel expressed in nociceptive primary sensory neurons. However, we previously showed that CA inhibits the L-type Ca2+ channel in cardiac and smooth muscle cells, raising the possibility that other ion channels can be modulated b

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